Peer Review Journals
   Discovery Studies
   Validation Studies
   IBDX Genetic Associations
   Review Articles 

Conferences 
   Oral/Platform Presentations
   Poster Presentations 

Peer Review Journals 

Validation Studies

Association of the novel serologic anti-glycan antibodies anti-laminarin and anti-chitin with complicated Crohn's disease behavior.
F Rieder, S Schleder, A Wolf, A Dirmeier, U Strauch, F Obermeier, R Lopez, L Spector, E Fire, J Yarden, G Rogler, N Dotan, F Klebl
Inflamm Bowel Dis 2010; 16: 263-274 

Association of the novel serologic anti-glycan antibodies anti-laminarin and anti-chitin with complicated Crohn's disease behavior
F Rieder, S Schleder, A Wolf, A Dirmeier, U Strauch, F Obermeier, R Lopez, L Spector, E Fire, J Yarden, G Rogler, N Dotan, F Klebl
Inflamm Bowel Dis 2009 Aug 3. [Epub ahead of print]

New serological markers for inflammatory bowel disease are associated with earlier age at onset, complicated disease behavior, risk for surgery, and NOD2/CARD15 genotype in a Hungarian IBD cohort.
M Papp, I Altorjay, N Dotan, K Palatka, I Foldi, J Tumpek, S Sipka, M Udvardy, T Dinya, L Lakatos, A Kovacs, T Molnar, Z Tulassay, P Miheller, GL Norman, T Szamosi, J Papp; Hungarian IBD Study Group and PL Lakatos
Am J Gastroentero 2008;103:665-681

Development of pouchitis following ileal pouch-anal anastomosis (IPAA) for ulcerative colitis: A role for serological markers and microbial pattern recognition receptor genes.
M Ferrante, S Declerck, T Coopmans, G De Hertogh, G Van Assche, F Penninckx, P Rutgeerts, K Geboes, A D'Hoore and S Vermeire
Journal of Crohn's and Colitis 2008;2:142-151
 
Antiglycan antibodies as serological markers in the differential diagnosis of inflammatory bowel disease
D Simondi, G Mengozzi, S Betteto, R Bonardi, RP Ghignone, S Fagoonee, R Pellicano, C Sguazzini, R Pagni, M Rizzetto and M Astegiano
Inflamm Bowel Dis 2008;14:645-651

Contribution of genetic and environmental factors in the pathogenesis of Crohn's disease in a large family with multiple cases
M Joossens, M Simoens, S Vermeire, X Bossuyt, K Geboes and P Rutgeerts
Inflamm Bowel Dis 2007;13:580-584 


Discovery Studies

Novel anti-glycan antibodies related to inflammatory bowel disease diagnosis and phenotype
CH Seow, JM Stempak, W Xu, H Lan, AM Griffiths, GR Greenberg, AH Steinhart, N Dotan, MS Silverberg
Am J Gastroentero 2009 doi: 10.1038/ajg.2009.79

Antibodies against glucan, chitin, and Saccharomyces cerevisiae mannan as new biomarkers of Candida albicans infection that complement tests based on C. albicans mannan
B Sendid, N Dotan, S Nseir, C Savaux, P Vandewalle, A Standaert, F Zerimech, BP Guery, A Dukler, JF Colombel and D Poulain
Clin Vaccine Immunol 2008;15:1868-1877

New serological markers in inflammatory bowel disease are associated with complicated disease behaviour
M Ferrante, L Henckaerts, M Joossens, M Pierik, Joossens S, N Dotan, GL Norman, RT Altstock, K Van Steen, P Rutgeerts, G Van Assche, S Vermeire
Gut 2007;56:1394-1403

Antibodies against laminaribioside and chitobioside are novel serologic markers in Crohn's disease
I Dotan, S Fishman, Y Dgani, M Schwartz, A Karban, A Lerner, O Weishauss, L Spector, A Shtevi, RT Altstock, N Dotan and Z Halpern
Gastroenterology 2006;131:366-378 


IBDX Genetic Associations

Interaction between seroreactivity to microbial antigens and genetics in Crohn's disease: is there a role for defensins?
PL Lakatos, I Altorjay, Y M?ndi, L Lakatos, J Tumpek, A Kovacs, T Molnar, Z Tulassay, P Miheller, K Palatka, T Szamosi, S Fischer, J Papp; Hungarian IBD Study Group and M Papp.
Tissue Antigens 2008;71:552-559

Mutations in pattern recognition receptor genes modulate seroreactivity to microbial antigens in patients with inflammatory bowel disease
L Henckaerts, M Pierik, M Joossens, M Ferrante, P Rutgeerts and S Vermeire
Gut 2007;56:1536-1542 

Review Articles 

Recent development in carbohydrate-based cancer vaccines.Endpoints for clinical trials evaluating disease modification and structural damage in adults with Crohn's disease 

New serological biomarkers of inflammatory bowel disease
X Li, L Conklin, and P Alex
World J Gastroenterol 2008;14:5115-5124 

Utility of serological markers in inflammatory bowel diseases: gadget or magic?
M Papp, GL Norman, I Altorjay, PL Lakatos
World J Gastroenterol 2007;13:2028-2036

Anti-glycan antibodies as biomarkers for diagnosis and prognosis
N Dotan, RT Altstock, M Schwarz, A Dukler
Lupus 2006;15:442-450

Role of biomarkers in the diagnosis of inflammatory bowel disease
S Vermeire, G Van Assche and P Rutgeerts
Expert Opin Med Diagn 2007 1:481-488
 
The role of microbes in Crohn's disease.
PB Eckburg, DA Relman.
Clin Infect Dis;44256-62... 2007 

CONFERENCES 

ORAL / PLATFORM PRESENTATIONS

2008 Digestive Disease Week

The novel anti-glycan antibodies Anti-L and Anti-C in conjunction with ALCA, ACCA, gASCA and AMCA predict early development of fistulae, stenoses and surgery in patients with Crohn's disease: a prospective analysis
F Rieder, A Wolf, S Schleder, A Dirmeier, U Strauch, F Obermeier, F Spector, E Fire, J Yarden, G Rogler, N Dotan, F Klebl
Gastroenterology 2008; 134:S1, A-53

Specific levels and combinations of the anti-glycan antibodies Anti-L, Anti-C, ALCA, ACCA, gASCA and AMCA contribute to diagnosis and differential diagnosis of patients with Crohn's disease and are associated with complicated disease and surgery
F Rieder, A Wolf, S Schleder, A Dirmeier, U Strauch, F Obermeier, F Spector, E Fire, J Yarden, G Rogler, N Dotan, F Klebl
Gastroenterology 2008; 134:S1, A-53

Two novel polysaccharide antibodies (anti-laminarin and anti-chitin) predict an aggressive Crohn's disease phenotype and improve differentiation between Crohn's disease and ulcerative colitis
CH Seow, JM Stempak, W Xu, H Lan, AM Griffiths, GR Greenberg, AH Steinhart, N Dotan, MS Silverberg
Gastroenterology 2008; 134:S1, A 53

2008 Canadian Digestive Disease Week

The utility of two novel polysaccharide antibodies (Anti-laminarin and anti-chitin) in diagnosing Crohn's disease and their association with aggressive disease
CH Seow, JM Stempak, W Xu, H Lan, AM Griffiths, GR Greenberg, AH Steinhart, N Dotan, and MS Silverberg
Can J Gastroenterol 2008; 22:SA, 78A

Serum ASCA and Smoking Status are Associated with a Crohn's Disease-like Phenotype after Pelvic Pouch Surgery for Ulcerative Colitis
D Verbeeten, R Milgrom, W Xu, J Stempak, A Hillary Steinhart, G Greenberg1, R McLeod1, Z Cohen1, MS Silverberg
Can J Gastroenterol 2009; 23:SA, 69A

2006 Digestive Disease Week

A panel of serological antibodies (gASCA, Omp, ACCA, ALCA and AMCA) predicts complicated disease course and surgery in Crohn's disease.
M Ferrante, M Pierik, L Henckaerts, N Dotan, GL Norman, RT Altstock, I Dotan, Z Shums, B Schooler, K Claes, N Van Schuerbeek, G Van Assche, P Rutgeerts and S Vermeire
Gastroenterology 2006,130:S2, A 25 

POSTER PRESENTATIONS

2008 Digestive Disease Week

Ulcerative colitis patients after pouch surgery have Crohn's disease associated serologies which are associated with pouch inflammation
I Dotan, H Tulchinsky, H Zinger, N Horowitz, I Goldiner, E Brazowski, Z Halpern
Gastroenterology 2008; 134:S1,A198

2008 16th United European Gastroenterology Week

Pancreatic autoantibodies are associated with reactivity to microbial antibodies, penetrating disease behavior, perianal disease and extraintestinal manifestations, but not with NOD2/CARD15 or TLR4 genotype in a HUNGARIAN IBD cohort
P L Lakatos, I. Altorjay, T Szamosi, K Palatka, Z Vitalis, J Tumpek, S Sipka, M Udvardy, T Dinya, L Lakatos, A Kovacs, T Molnar, Z Tulassay, P Miheller, Z Barta, . Stocker, J Papp, Hungarian IBD Study Group, M. Papp
UEGW 2008 - Abstract Database, P0168
http://www.uegf.org/publications/abstracts2008/abstract_detail.php?aId=P0168&navId=218

Fungal colonization of gastrointestinal tract, anti-saccharomyces cervisiae antibodies anti-mannan candida Spp. antibodies in inflammatory bowel disease in comparison with irritable bowel syndrome
J. Semianow-Wejchert, U. Nawrot, D. Ksiadzyna, K. Wlodarczyk, A. Annabhani
UEGW 2008 - Abstract Database, P0683
http://www.uegf.org/publications/abstracts2008/abstract_detail.php?aId=P0683&navId=218

Novel biomarkers of Crohn's disease consisting in antibodies against synthetic disaccharides fragments of glucan and chitin (ALCA and ACCA), as well as ASCA, are generated during a Candida Albicans infection
B Sendid, C Savaux, N Dotan, P Vandewalle, L Richard, A Standaert, B Guery, A Dukler, J Colombel, D Poulain
UEGW 2008 - Abstract Database, P0136
http://www.uegf.org/publications/abstracts2008/abstract_detail.php?aId=P0136&navId=218

2007 15th United European Gastroenterology Week

Anti-glycan antibodies markers are useful for differentiation between Crohn's disease and ulcerative colitis in children
N Dotan, RT Altstock, E Fire, M Gortler, L Spector, JM Stempak, AM Griffiths, MS Silverberg
Gut 2007;56:S3, A137

Increasing prevalence of anti-glycan antibodies markers associated with aggressive CD behavior in a Canadian cohort
N Dotan, A Elkadri, AH Steinhart, GR Greenberg, RS McLeod, Z Cohen, E Fire, RT Altstock, L Spector, M Gortler, JM Stempak, MS Silverberg
Gut 2007; 56:S3, A137

Anti-glycan antibodies in celiac disease before and after gluten-free diet
M Papp, I Foldi, J Tumpek, C Varvolgyi, Z Bartha, S Sipka, N Dotan, IR Korponay-Szab?, E Nemes, V G?bor, I Altorjay, PL Lakatos
Gut 2007; 56:S3, A109

Comparing conventional and gASCA tests for the diagnosis and determination of clinical phenotype in Crohn's disease
P L Lakatos, I Altorjay, N Dotan, J Tumpek, S Sipka, G Lakos, M Udvardy, K Palatka, L Lakatos, A Kovacs, T Molnar, Z Tulassay, P Miheller, G L Norman, Z Shums, T Szamosi, J Papp, the Hungarian IBD Study Group*, M Papp
Gut 2007; 56:S3, A119

2007 Digestive Disease Week

Serum levels of AMCA, ALCA, ACCA and gASCA in conjunction with pANCA may contribute to the diagnosis and differentiation of inflammatory bowel disease
F Rieder, A Wolf, S Schleder, A Dirmeier, M Gruengard, U Strauch, F Obermeier, B Salzberger, Rogler G, Dotan N, Klebl F
Gastroenterology 2007; 132: No.4, S2: A-652

2006 Digestive Disease Week

Mutations in innate immune receptors modulate the serologic response to microbial antigens in patients with inflammatory bowel disease
L Henckaerts, M Pierik, K Claes, M Ferrante, N Van Schuerbeek, N Dotan, G Norman, RT Altstock, I Dotan, B Schooler, Z Shums, P Rutgeerts, S Vermeire
Gastroenterology 2006,130:S2, T1974: A-585

A panel of Anti-Glycan Antibodies (gASCA, ALCA, ACCA and AMCA) in the diagnosis and differential diagnosis of IBD
M Ferrante, M Pierik, L Henckaerts, N Dotan, RT Altstock, I Dotan, M Joossens, S Joossens, K Katsanos, K Claes, N Van Schuerbeek, G Van Assche, P Rutgeerts and S Vermeire. Gastroenterology 2006;130:S2, S1315: A-200

Anti-laminaribioside and anti-chitobioside antibodies as predictors of Crohn's disease
E Israeli, I Grotto, M Blank, L Anafi, E Goldin and Y Shoenfeld
Gastroenterology 2006;130: S2:S1369: A-212

2005 Digestive Disease Week

Improved IBD diagnosis via ELISA detecting novel antibodies: Anti-chitobioside carbohydrate antibodies (ACCA), anti-laminaribioside carbohydrate antibodies (ALCA) and anti-mannobioside carbohydrate antibodies (AMCA)RT Altstock, 
A Shtevi, A Karban, N Dotan, Z Halpern, I Dotan
Gastroenterology 2005;128:A-303.

Mixed IBD Families: A distinct entity within IBD
M Joossens, M Pierik, L Henckaerts, S Joossens, K. Claes, P Rutgeerts, S Vermeire
Gastroenterology 2006; 130:S2

2004 Digestive Disease Week

Anti-Laminarobioside Carbohydrate Antibodies (ALCA) and Anti-Chitobiose Carbohydrate Antibodies (ACCA) are Novel Serologic Markers Specific for Crohn's Disease
I Dotan, S Fishman, R Kariv, Y Dgani, M Schwartz, A Gargir, L Spector, R Altstock, Z Halpern, N Dotan
Gastroenterology 2004;125 S2:A203
Z Guo , Q Wang, Curr Opin Chem Biol. 2009
GR D'Haens, R Fedorak, M Lémann, BG Feagan, MA Kamm, J Cosnes, PJ Rutgeerts, P Marteau, S Travis, J Schölmerich, S Hanauer, WJ Sandborn; IOIBD Membership.
Inflamm Bowel Dis. 2009 ;10:1599-604